Esiri M M
J Neurol Sci. 1982 May;54(2):209-26. doi: 10.1016/0022-510x(82)90183-6.
An immunoperoxidase technique was used to map the sites of herpes simplex virus antigen (VA) within the brain in 29 autopsied cases of herpes simplex encephalitis. Attention was directed particularly to those parts of the brain that are known from pathological studies to be involved in the disease. Material was studied from cases surviving for varying periods from a few days to a few years after the onset of neurological disease. VA was found within the brain in all cases dying within 3 weeks of onset, but in none dying thereafter. VA was already most abundant in patients dying within the first week and remained plentiful during the first 16 days. Inflammation and necrosis reached a peak when detectable virus was waning. VA was concentrated mainly in the medial and inferior temporal lobes, hippocampus, amygdaloid nuclei, olfactory cortex, insula and cingulate gyrus. It was invariably present on both sides of the brain but was more abundant on one side than the other. Virus was found in glial cells of the olfactory tracts but not in relation to trigeminal pathways. Attention is drawn to focally extensive infection of the granule cell of the dentate fascia, and the possible significance of this finding is discussed.
采用免疫过氧化物酶技术，对29例单纯疱疹性脑炎尸检病例脑内单纯疱疹病毒抗原（VA）的部位进行了定位。特别关注了病理研究已知与该病有关的脑区。研究材料取自神经疾病发病后存活不同时间（从几天到几年）的病例。在发病后3周内死亡的所有病例脑内均发现了VA，但此后死亡的病例中均未发现。在发病后第一周内死亡的患者中，VA已最为丰富，并在最初16天内一直大量存在。当可检测到的病毒减少时，炎症和坏死达到高峰。VA主要集中在内侧和颞下叶、海马体、杏仁核、嗅觉皮质、脑岛和扣带回。它总是在脑的两侧出现，但一侧比另一侧更丰富。在嗅束的神经胶质细胞中发现了病毒，但与三叉神经通路无关。注意到齿状筋膜颗粒细胞的局灶性广泛感染，并讨论了这一发现的可能意义。
