Papadimitriou M, Milionis A, Sakellariou G, Metaxas P
Nephron. 1978;20(3):157-62. doi: 10.1159/000181214.
The effect of furosemide on the development of the acute ischaemic renal failure in the dog was studied. 11 canine kidneys were used as controls (group I) and 12 as a group where furosemide (6-8 mg/kg of body weight) was given (group II) immediately after releasing the clamps. Urine volume and sodium clearance were found significantly higher in the second group of kidneys during a period of 60 min after restoration of the blood flow to the kidney. Urea clearances remained low with no noted difference between the 2 groups. By the end of the first hour osmolar and potassium clearances were found to be significantly higher in the second group. The above findings suggest that furosemide given after an induction of acute ischaemic renal failure in the dog provides, up to the 1st hour after recirculation, some benefit in water and solute excretion but no benefit in urea clearance.
研究了速尿对犬急性缺血性肾衰竭发展的影响。11个犬肾用作对照组（第一组），12个犬肾在松开血管夹后立即给予速尿（6 - 8毫克/千克体重）作为一组（第二组）。在恢复肾脏血流后的60分钟内，发现第二组肾脏的尿量和钠清除率显著更高。两组之间尿素清除率仍然较低且无明显差异。在第一个小时结束时，发现第二组的渗透清除率和钾清除率显著更高。上述发现表明，在犬急性缺血性肾衰竭诱导后给予速尿，在再循环后的第1小时内，对水和溶质排泄有一定益处，但对尿素清除率无益处。
