Lindner A, Cutler R E, Goodman G
Kidney Int. 1979 Aug;16(2):158-66. doi: 10.1038/ki.1979.117.
The protective effects of a combination of dopamine and furosemide were studied in dogs during the initial phase of acute renal failure (ARF) induced by intravenous uranyl nitrate (10 mg/kg). Fifteen minutes after injection of the nephrotoxin, and infusion of dopamine (3 micrograms/kg/min), furosemide (1 mg/kg/bolus followed by 1 mg/kg/hr), or both drugs simultaneously were given for 6 hours. Exogenous creatinine clearance was measured for 6 hours, and the intrarenal blood flow was measured with radioactive microspheres before and 3 hours after the induction of ARF. Treatment with both dopamine and furosemide produced renal vasodilatation, high urine flow rate, and attenuation of the fall in GRF seen in untreated animals. In contrast, single use of dopamine or furosemide was totally ineffective in producing renal vasodilation, a diuresis, or the maintenance of the GFR. These data indicate that dopamine plus furosemide have a synergistic effect in preventing the early pathophysiologic changes associated with ARF in this animal model. Maintenance of a high GFR correlated best with the enhancement of solute excretion and urine flow rate. Potential protective effects of dopamine plus furosemide in other models of ARF deserve careful investigation.
在静脉注射硝酸铀酰（10毫克/千克）诱导的急性肾衰竭（ARF）初始阶段，研究了多巴胺和呋塞米联合使用对犬的保护作用。注射肾毒素15分钟后，输注多巴胺（3微克/千克/分钟）、呋塞米（1毫克/千克推注，随后1毫克/千克/小时）或同时给予两种药物，持续6小时。测量6小时的外源性肌酐清除率，并在诱导ARF前及诱导后3小时用放射性微球测量肾内血流量。多巴胺和呋塞米联合治疗可使肾血管舒张、尿流率升高，并减轻未治疗动物中出现的肾小球滤过率（GRF）下降。相比之下，单独使用多巴胺或呋塞米在产生肾血管舒张、利尿或维持肾小球滤过率方面完全无效。这些数据表明，多巴胺加呋塞米在预防该动物模型中与ARF相关的早期病理生理变化方面具有协同作用。维持高肾小球滤过率与溶质排泄和尿流率的增加最为相关。多巴胺加呋塞米在其他急性肾衰竭模型中的潜在保护作用值得仔细研究。
