Hoversland R C, Dey S K, Johnson D C
Life Sci. 1982 May 24;30(21):1801-4. doi: 10.1016/0024-3205(82)90316-2.
Induction of implantation is among the most sensitive responses to estrogens. The ability of catechol estradiols, 4-hydroxy-estradiol-17 beta (4-OH-E2) and 2-hydroxy-estradiol-17 beta (2-OH-E2), to induce implantation in ovariectomized pregnant mice was compared to that of estradiol-17 beta. Delayed implantation was maintained by the daily administration of 2 mg of progesterone. A single injection of 3 ng of estradiol-17 beta, 50 ng of 4-OH-E2, or 2,000 ng of 2-OH-32 consistently induce a full complement of implantation sites in all animals. Before the estrogenicity of the latter steroid can be established the lack of contaminating estrogens must be proved.
诱导着床是对雌激素最敏感的反应之一。将儿茶酚雌二醇、4-羟基雌二醇-17β（4-OH-E2）和2-羟基雌二醇-17β（2-OH-E2）诱导去卵巢怀孕小鼠着床的能力与17β-雌二醇的能力进行了比较。通过每日注射2mg孕酮维持延迟着床。单次注射3ng 17β-雌二醇、50ng 4-OH-E2或2000ng 2-OH-E2可在所有动物中一致诱导出完整的着床位点。在确定后一种类固醇的雌激素活性之前，必须证明不存在污染性雌激素。
