State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China; Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China.
Mol Aspects Med. 2013 Oct;34(5):939-80. doi: 10.1016/j.mam.2012.12.011. Epub 2013 Jan 2.
Embryo implantation involves the intimate interaction between an implantation-competent blastocyst and a receptive uterus, which occurs in a limited time period known as the window of implantation. Emerging evidence shows that defects originating during embryo implantation induce ripple effects with adverse consequences on later gestation events, highlighting the significance of this event for pregnancy success. Although a multitude of cellular events and molecular pathways involved in embryo-uterine crosstalk during implantation have been identified through gene expression studies and genetically engineered mouse models, a comprehensive understanding of the nature of embryo implantation is still missing. This review focuses on recent progress with particular attention to physiological and molecular determinants of blastocyst activation, uterine receptivity, blastocyst attachment and uterine decidualization. A better understanding of underlying mechanisms governing embryo implantation should generate new strategies to rectify implantation failure and improve pregnancy rates in women.
胚胎着床涉及着床能力强的囊胚与接受性子宫之间的密切相互作用,该过程发生在一个有限的时间窗口,称为着床窗口。新出现的证据表明,胚胎着床过程中出现的缺陷会引发连锁反应,对后期妊娠事件产生不利影响,突出了这一事件对妊娠成功的重要性。虽然通过基因表达研究和基因工程小鼠模型已经确定了胚胎-子宫相互作用过程中涉及的大量细胞事件和分子途径,但对胚胎着床本质的全面理解仍有所缺失。本综述重点关注近期的进展,并特别关注囊胚激活、子宫容受性、囊胚附着和子宫蜕膜化的生理和分子决定因素。更好地理解控制胚胎着床的潜在机制,应能产生新的策略来纠正着床失败并提高女性的妊娠率。