Guillevin L, Janot F, Beaufils H, Godeau P
Sem Hop. 1982 May 20;58(20):1221-3.
Acute glomerulopathy due to pneumococcal infection occurred in a patient with chronic discoid lupus. The onset of renal involvement in this context suggested that cutaneous lupus may have developed into systemic lupus erythematosus. Renal biopsy established the correct diagnosis. The physiopathology of glomerular involvement in lupus and infections is discussed. Attention is drawn to the significance of complement activation, either by the classical or the alternative pathways according to the etiology.
一名慢性盘状狼疮患者发生了由肺炎球菌感染引起的急性肾小球病。在这种情况下肾脏受累的发作提示皮肤狼疮可能已发展为系统性红斑狼疮。肾活检确立了正确的诊断。文中讨论了狼疮和感染中肾小球受累的生理病理学。根据病因,强调了补体通过经典途径或替代途径激活的重要性。