Gairola C, Chow C K
Toxicol Lett. 1982 May;11(3-4):281-7. doi: 10.1016/0378-4274(82)90162-x.
The effect of dietary selenium (Se) on the hepatic aryl hydrocarbon hydroxylase (AHH) and mutagenic activation potential in young and adult rats was investigated. Animals were maintained on a low Se basal diet with or without 1 or 2 ppm Se supplementation (as sodium selenite) for 5 or 20 weeks. AHH inducibility was determined by an intraperitoneal injection of Aroclor 5 days prior to killing. A significant reduction in the AHH level was observed in low Se group of young untreated rats only. Dietary Se did not affect AHH inducibility by Aroclor treatment and the induced AHH levels were similar in both dietary groups. 5 weeks on low dietary Se did not alter the AHH levels in untreated or treated adult rats. The levels of Se-dependent glutathione peroxidase (GSH-P) were decreased more drastically in the young than adult rats by low dietary Se. Studies on the metabolic activation potential of liver enzymes from young rats on basal and Se-supplemented diets showed that dietary Se did not alter the activation of benzo(a)pyrene (BP) to mutagens although differences in the activation of 2-aminofluorene (2AF) and 2-aminoanthracene (2AA) were observed.
研究了膳食硒（Se）对幼年和成年大鼠肝脏芳烃羟化酶（AHH）及诱变激活潜力的影响。动物被饲养在低硒基础日粮上，添加或不添加1或2 ppm硒（以亚硒酸钠形式），持续5周或20周。在处死前5天通过腹腔注射多氯联苯混合物来测定AHH诱导能力。仅在未处理的幼年低硒组大鼠中观察到AHH水平显著降低。膳食硒不影响多氯联苯混合物处理诱导的AHH能力，且两个膳食组中诱导的AHH水平相似。低膳食硒喂养5周未改变未处理或处理过的成年大鼠的AHH水平。低膳食硒使幼年大鼠中硒依赖性谷胱甘肽过氧化物酶（GSH-P）水平的降低幅度比成年大鼠更大。对基础日粮和补硒日粮喂养的幼年大鼠肝脏酶的代谢激活潜力研究表明，膳食硒虽未改变苯并(a)芘（BP）向诱变剂的激活，但观察到2-氨基芴（2AF）和2-氨基蒽（2AA）激活存在差异。
