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阿昔洛韦的化学性质与活性谱。

Acyclovir chemistry and spectrum of activity.

作者信息

Schaeffer H J

出版信息

Am J Med. 1982 Jul 20;73(1A):4-6. doi: 10.1016/0002-9343(82)90054-7.

DOI:10.1016/0002-9343(82)90054-7
PMID:6285730
Abstract

Most antiviral agents with activity against the herpes group of viruses belong to a class of compounds known as nucleosides. Recently, an acyclic analog of a natural nucleoside has been found to have high activity against the herpes virus. This compound, called generically acyclovir, is 9-(hydroxymethyl)guanine. Its spectrum of antiviral activity is described.

摘要

大多数对疱疹病毒群有活性的抗病毒剂属于一类称为核苷的化合物。最近,一种天然核苷的无环类似物被发现对疱疹病毒具有高活性。这种化合物,通用名为阿昔洛韦,是9-(羟甲基)鸟嘌呤。描述了其抗病毒活性谱。

相似文献

1
Acyclovir chemistry and spectrum of activity.阿昔洛韦的化学性质与活性谱。
Am J Med. 1982 Jul 20;73(1A):4-6. doi: 10.1016/0002-9343(82)90054-7.
2
Purine acyclic nucleosides. Nitrogen isosteres of 9-[(2-hydroxyethoxy)methyl]guanine as candidate antivirals.嘌呤无环核苷。9-[(2-羟乙氧基)甲基]鸟嘌呤的氮类似物作为候选抗病毒药物。
J Med Chem. 1981 Dec;24(12):1528-31. doi: 10.1021/jm00144a033.
3
Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents.无环硒嘌呤核苷作为抗病毒药物的构效关系
Molecules. 2017 Jul 12;22(7):1167. doi: 10.3390/molecules22071167.
4
Pyrimidine acyclic nucleosides, 1-[(2-Hydroxyethoxy)methyl]pyrimidines as candidate antivirals.嘧啶无环核苷,1-[(2-羟乙氧基)甲基]嘧啶作为潜在的抗病毒药物。
J Med Chem. 1981 Jun;24(6):753-6. doi: 10.1021/jm00138a022.
5
Synthesis and antiviral activity of novel acyclic nucleosides: discovery of a cyclopropyl nucleoside with potent inhibitory activity against herpesviruses.新型无环核苷的合成与抗病毒活性:一种对疱疹病毒具有强效抑制活性的环丙基核苷的发现
J Med Chem. 1998 Apr 9;41(8):1284-98. doi: 10.1021/jm9705869.
6
Acyclovir-resistant herpes simplex virus.阿昔洛韦耐药的单纯疱疹病毒
N Engl J Med. 1982 Sep 9;307(11):681-2. doi: 10.1056/NEJM198209093071112.
7
Nucleoside analogues as antiviral agents.核苷类似物作为抗病毒药物。
Acta Microbiol Acad Sci Hung. 1981;28(3):289-306.
8
Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl}guanine analogues.三环阿昔洛韦的6-杂芳基衍生物和9-{[顺式-1',2'-双(羟甲基)环丙-1'-基]甲基}鸟嘌呤类似物的合成及抗水痘带状疱疹病毒活性
Eur J Med Chem. 2009 Aug;44(8):3313-7. doi: 10.1016/j.ejmech.2009.03.005. Epub 2009 Mar 21.
9
Sensitivity of herpes virus isolates from acyclovir clinical trials.来自阿昔洛韦临床试验的疱疹病毒分离株的敏感性。
Am J Med. 1982 Jul 20;73(1A):380-2. doi: 10.1016/0002-9343(82)90127-9.
10
Synthesis and antiviral activity of carbocyclic oxetanocin analogues (C-OXT-A, C-OXT-G) and related compounds. II.
Chem Pharm Bull (Tokyo). 1993 Mar;41(3):516-21. doi: 10.1248/cpb.41.516.

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Pharmacotherapy variability and precision medicine in neurocritical care.神经重症监护中的药物治疗变异性与精准医学
Front Neurol. 2025 Jul 18;16:1630163. doi: 10.3389/fneur.2025.1630163. eCollection 2025.
2
Treatment of recurrent eczema herpeticum in pregnancy with acyclovir.妊娠期复发性疱疹样湿疹的阿昔洛韦治疗
Infect Dis Obstet Gynecol. 1996;4(4):239-42. doi: 10.1155/S1064744996000452.
3
Viral skin infections: diagnosis and treatment considerations.病毒性皮肤感染:诊断与治疗考量
Drugs. 2002;62(3):479-90. doi: 10.2165/00003495-200262030-00005.
4
Clinical pharmacokinetics of acyclovir.阿昔洛韦的临床药代动力学
Clin Pharmacokinet. 1983 May-Jun;8(3):187-201. doi: 10.2165/00003088-198308030-00001.
5
Acyclovir. A review of its pharmacodynamic properties and therapeutic efficacy.阿昔洛韦。对其药效学特性及治疗效果的综述。
Drugs. 1983 Nov;26(5):378-438. doi: 10.2165/00003495-198326050-00002.