Leipzig B, Gonzales-Vitale J C
Arch Otolaryngol. 1982 Aug;108(8):511-4. doi: 10.1001/archotol.1982.00790560049015.
Two patients had small cell carcinomas of the salivary glands, with pathological features indicating squamous differentiation, heretofore not described. One is free of disease at seven years, and the second is alive, with regional metastases at four years. Sections from one tumor were studied by electron microscopy and revealed tonofilaments and desmosomes. Most cases of small cell carcinomas of the salivary glands have been considered akin to bronchogenic oat cell carcinoma. Their less aggressive behavior, however, suggests that at least some of these tumors were not true oat cell carcinomas. Our findings, and those of others, indicate that small cell carcinomas of the salivary glands (or head and neck) represent a heterogeneous group. Electron microscopy should be used to determine the exact nature of these neoplasms. If an oat cell nature is ruled out, local and regional treatment should be aggressive, since small cell carcinomas other than oat cell appear not to have a dismal prognosis.
两名患者患有涎腺小细胞癌，其病理特征显示有鳞状分化，此前未见相关描述。一名患者7年后无疾病迹象，另一名患者存活，4年后出现区域转移。对其中一个肿瘤的切片进行电子显微镜检查，发现有张力丝和桥粒。大多数涎腺小细胞癌病例被认为类似于支气管源性燕麦细胞癌。然而，它们侵袭性较小的行为表明，这些肿瘤中至少有一些并非真正的燕麦细胞癌。我们的研究结果以及其他研究结果表明，涎腺（或头颈部）小细胞癌是一组异质性肿瘤。应使用电子显微镜来确定这些肿瘤的确切性质。如果排除了燕麦细胞性质，局部和区域治疗应积极进行，因为除燕麦细胞癌外的小细胞癌似乎预后并不差。
