Gnepp D R, Corio R L, Brannon R B
Cancer. 1986 Aug 1;58(3):705-14. doi: 10.1002/1097-0142(19860801)58:3<705::aid-cncr2820580318>3.0.co;2-t.
Small cell carcinoma is primarily a pulmonary neoplasm that rarely arises in extrapulmonic sites including salivary glands of the head and neck. Twelve cases of small cell carcinoma of salivary gland origin were retrieved from the Armed Forces Institute of Pathology files. Six tumors occurred in the parotid gland and six in the submandibular gland. Tumors were classified into two categories: those with areas of histologically typical small cell carcinoma (7 cases) and those with areas of typical small cell carcinoma with foci of ductal differentiation (5 cases). Follow-up information was available in all 12 cases. Electron microscopy was done on eight tumors; only one demonstrated round electron dense intracytoplasmic neurosecretory granules. These observations further support evidence in the literature suggesting most of the small cell carcinomas of salivary gland origin are not true neuroendocrine ("oat cell") carcinomas, but actually are small cell ductal carcinomas. These tumors appear to have a better prognosis than small cell carcinoma of the lung or nonsalivary gland sites in the head and neck region, with an estimated 2- and 5-year survival of 70 and 46%, respectively.
小细胞癌主要是一种肺部肿瘤，很少发生于肺外部位，包括头颈部的唾液腺。从武装部队病理研究所档案中检索到12例唾液腺起源的小细胞癌。6例肿瘤发生在腮腺，6例发生在下颌下腺。肿瘤分为两类：具有组织学典型小细胞癌区域的肿瘤（7例）和具有典型小细胞癌区域伴导管分化灶的肿瘤（5例）。所有12例均有随访信息。对8例肿瘤进行了电子显微镜检查；仅1例显示有圆形电子致密的胞质内神经分泌颗粒。这些观察结果进一步支持了文献中的证据，表明大多数唾液腺起源的小细胞癌并非真正的神经内分泌（“燕麦细胞”）癌，而实际上是小细胞导管癌。这些肿瘤的预后似乎比肺癌或头颈部非唾液腺部位的小细胞癌要好，估计2年和5年生存率分别为70%和46%。
