Rubel L R, Ishak K G
Cancer. 1982 Oct 1;50(7):1408-15. doi: 10.1002/1097-0142(19821001)50:7<1408::aid-cncr2820500728>3.0.co;2-t.
Six cases of Thorotrast-associated cholangiocarcinoma (TACC) are studied and compared with eight previously reported cases as well as with cases of non-TACC. TACC shares some epidemiologic features both with non-TACC as well as Thorotrast-associated angiosarcoma (TAAS) but appears to occur in younger patients than non-TACC. There is an apparent increased prevalence of both benign and malignant thyroid disease in the current group of patients with TACC; previous epidemiologic studies have not identified this phenomenon. Thorotrast-associated hepatic fibrosis was present in all 14 TACC cases; otherwise, both non-TACC and TACC are clinically and morphologically similar. Bile duct dysplasia and/or transition to adenocarcinoma, which occurred in all the AFIP cases, are seldom described in case reports of either TACC or non-TACC; in the current study they served to validate the intrahepatic origin of the tumors.
对6例钍造影剂相关胆管癌（TACC）进行了研究，并与8例先前报道的病例以及非TACC病例进行了比较。TACC与非TACC以及钍造影剂相关血管肉瘤（TAAS）具有一些流行病学特征，但似乎比非TACC发生在更年轻的患者中。在目前的TACC患者组中，良性和恶性甲状腺疾病的患病率明显增加；以前的流行病学研究尚未发现这一现象。14例TACC病例均存在钍造影剂相关肝纤维化；否则，非TACC和TACC在临床和形态上相似。胆管发育异常和/或向腺癌的转变在所有AFIP病例中均有发生，在TACC或非TACC的病例报告中很少描述；在本研究中，它们用于验证肿瘤的肝内起源。
