Kameda Y
Cell Tissue Res. 1982;225(2):315-8. doi: 10.1007/BF00214684.
When stimulated by the feeding of ethylenethiourea for a period of 6 months, dog thyroid glands increased to approximately 30 times their normal size. Not only follicular cells but also C cells had hyperplastic and hypertrophic features, compared with normal controls there was in the C cells a marked decrease in secretory granules immunoreactive for calcitonin. Furthermore, vesicular inclusions of various sizes and dilated nuclear enveloped, which showed a positive immunoreaction for calcitonin, were observed in the C cells. These findings indicate that the antithyroid drug interferes with synthesis of calcitonin by C cells probably by inhibiting the conversion of a larger precursor to calcitonin by C cells, probably by inhibiting the conversion of a larger precursor to calcitonin.
当用乙撑硫脲喂养6个月进行刺激时，犬甲状腺增大至正常大小的约30倍。与正常对照相比，不仅滤泡细胞而且C细胞都具有增生和肥大的特征，C细胞中降钙素免疫反应性分泌颗粒明显减少。此外，在C细胞中观察到各种大小的泡状内含物和扩张的核膜，它们对降钙素呈阳性免疫反应。这些发现表明，抗甲状腺药物可能通过抑制C细胞将较大前体转化为降钙素，从而干扰C细胞降钙素的合成。
