Wehrenberg W B, Wardlaw S L, Frantz A G, Ferin M
Endocrinology. 1982 Sep;111(3):879-81. doi: 10.1210/endo-111-3-879.
Concentrations of beta-endorphin were measured in the venous effluent of the hypothalamus (hypophyseal portal blood) at various phases of the menstrual cycle and after ovariectomy in rhesus and pigtailed monkeys. In the rhesus, beta-endorphin concentrations were high during the mid- to late follicular phase [737 +/- 256 pg/ml (mean +/- SE)] and the luteal phase (1675 +/- 1108) of the menstrual cycle, but were undetectable (less than 133) at menstruation. Concentrations were also high in pigtailed monkeys during stages of the menstrual cycle other than at menstruation (4870 +/- 1090 pg/ml), but undetectable (less than 133) 4--12 months after ovariectomy. These results indicate that beta-endorphin concentrations in hypophyseal portal blood are related to menstrual cycle events, probably changes in ovarian steroids; this in turn suggests that beta-endorphin may participate in the ovarian feedback regulation of gonadotropin secretion.
在恒河猴和豚尾猴的月经周期不同阶段以及卵巢切除术后，测量了下丘脑静脉流出液（垂体门脉血）中β-内啡肽的浓度。在恒河猴中，月经周期的卵泡中期至晚期[737±256皮克/毫升（平均值±标准误）]和黄体期（1675±1108）时β-内啡肽浓度较高，但在月经期无法检测到（低于133）。豚尾猴在月经周期除月经期外的其他阶段β-内啡肽浓度也较高（4870±1090皮克/毫升），但卵巢切除术后4至12个月无法检测到（低于133）。这些结果表明，垂体门脉血中β-内啡肽浓度与月经周期事件相关，可能与卵巢类固醇的变化有关；这反过来表明β-内啡肽可能参与促性腺激素分泌的卵巢反馈调节。
