对鼠巨细胞病毒的迟发型超敏反应及其在孕期的减弱
Delayed hypersensitivity to murine cytomegalovirus and its depression during pregnancy.
作者信息
Chong K T, Mims C A
出版信息
Infect Immun. 1982 Jul;37(1):54-9. doi: 10.1128/iai.37.1.54-59.1982.
A delayed hypersensitivity skin test for murine cytomegalovirus is described, in which ear swelling is measured after injection of heat-killed virus. The response appeared within 4 days of infection, peaked at 8 days, and remained at high levels for at least 100 days. When live virus was inoculated into the ear of previously uninfected mice, a much greater degree of ear swelling was seen, maximal at 7 days, but without growth of virus in the inoculated ear. Mice infected with avirulent (cell culture-passaged) virus gave greater delayed hypersensitivity responses than with those infected with virulent (salivary gland-passaged) virus. One of the strains of mice that is susceptible to murine cytomegalovirus (C57BL) developed greater delayed hypersensitivity responses than did the resistant strain (C3H). The delayed hypersensitivity response of neonatally infected mice was greatly depressed during pregnancy and lactation.
本文描述了一种针对鼠巨细胞病毒的迟发型超敏皮肤试验，即在注射热灭活病毒后测量耳部肿胀情况。该反应在感染后4天内出现，8天达到峰值，并至少持续高水平100天。当将活病毒接种到先前未感染的小鼠耳部时，可见耳部肿胀程度更大，在7天时达到最大值，但接种耳部未出现病毒生长。感染无毒力（细胞培养传代）病毒的小鼠比感染毒力（唾液腺传代）病毒的小鼠产生更强的迟发型超敏反应。对鼠巨细胞病毒易感的一种小鼠品系（C57BL）比抗性品系（C3H）产生更强的迟发型超敏反应。新生期感染小鼠的迟发型超敏反应在怀孕和哺乳期会大幅降低。
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