亚急性硬化性全脑炎病毒和巨细胞病毒感染中的淋巴细胞活化。对病毒感染细胞系的体外刺激反应。
Lymphocyte activation in subacute sclerosing panencephalitis virus and cytomegalovirus infections. In vitro stimulation in response to viral-infected cell lines.
作者信息
Thurman G B, Ahmed A, Strong D M, Knudsen R C, Grace W R, Sell K W
出版信息
J Exp Med. 1973 Oct 1;138(4):839-46. doi: 10.1084/jem.138.4.839.
Abstract
Efforts to stimulate lymphocytes from measles seropositive and two patients with subacute sclerosing panencephalitis (SSPE) with either commercially available measles virus or virus isolated from a known case of SSPE failed to show any significant data using a microculture assay. Similar results were obtained using lymphocytes from two patients with active cytomegalovirus (CMV) infections and CMV seropositive individuals using CMV suspensions. On the other hand, lymphocytes from the patients with subacute sclerosing panencephalitis exhibited in vitro blastogenesis in culture with SSPE virus-infected HeLa cells. Similarly, lymphocytes from the CMV-infected patients demonstrated blastogenesis when cocultivated with CMV-infected WI-38 cells. This affords a new method for determining the cell-mediated immune capacity of patients with "slow" virus diseases.
摘要
用市售麻疹病毒或从已知亚急性硬化性全脑炎（SSPE）病例分离出的病毒刺激麻疹血清阳性患者以及两名亚急性硬化性全脑炎患者的淋巴细胞，使用微量培养试验未能得出任何显著数据。用巨细胞病毒（CMV）悬液刺激两名活动性巨细胞病毒感染患者和巨细胞病毒血清阳性个体的淋巴细胞，也得到了类似结果。另一方面，亚急性硬化性全脑炎患者的淋巴细胞在与SSPE病毒感染的HeLa细胞共培养时，在体外表现出母细胞形成。同样，巨细胞病毒感染患者的淋巴细胞与巨细胞病毒感染的WI-38细胞共培养时也表现出母细胞形成。这为确定“慢”病毒疾病患者的细胞介导免疫能力提供了一种新方法。
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