Szeinberg A, Avigad S, Horwiz A, Jonas A
Isr J Med Sci. 1982 Jul;18(7):785-8.
In order to elucidate the importance of alpha 1-antitrypsin (AAT) deficiency as a cause of liver disease in children in Israel, we conducted a retrospective 5-yr study. The screening of 51 liver biopsies for the presence of AAT inclusion bodies was performed using the immunoperoxidase technique. Serum AAT concentrations of 300 pediatric patients determined during the same period were reviewed. No case of AAT deficiency was detected. We conclude that AAT deficiency is rare in Israel.
为阐明α1-抗胰蛋白酶(AAT)缺乏作为以色列儿童肝病病因的重要性,我们进行了一项为期5年的回顾性研究。采用免疫过氧化物酶技术对51份肝活检标本进行AAT包涵体筛查。回顾了同期测定的300例儿科患者的血清AAT浓度。未检测到AAT缺乏病例。我们得出结论,AAT缺乏在以色列很罕见。