Rojas A, Stewart F A, Denekamp J
Int J Radiat Oncol Biol Phys. 1982 Mar-Apr;8(3-4):527-30. doi: 10.1016/0360-3016(82)90676-9.
The data from a large series of experiments on mouse skin and tumors are summarized. Radioprotection with WR-2721 has been observed in both tumors and normal tissues. The protection factors are generally, but not always, higher for skin than for tumors. The protection observed in skin is greater for mice irradiated breathing air than for those irradiated in oxygen. It is postulated that the different protection factors observed in different normal tissues and tumors may reflect differences in tissue oxygenation levels. The combination of misonidazole and WR-2721 has been studied in terms of the modification of radiosensitivity and also as the modification of lethal toxicity. An interaction has been observed in all aspects. The toxicity of WR-2721 increases in the presence of misonidazole. The WR-2721 radioprotection of both skin and tumors decreases if the sensitizer is added. Likewise the radiosensitization with misonidazole is diminished when WR-2721 is present. These results indicate an interaction at the site of radiation injury and they also demonstrate that WR-2721 can adequately penetrate into hypoxic tumor cells.
总结了一系列对小鼠皮肤和肿瘤进行的大量实验数据。在肿瘤和正常组织中均观察到WR - 2721的辐射防护作用。皮肤的防护因子通常（但并非总是）高于肿瘤。对于吸入空气照射的小鼠，皮肤中观察到的防护作用比对在氧气中照射的小鼠更大。据推测，在不同正常组织和肿瘤中观察到的不同防护因子可能反映了组织氧合水平的差异。已就米索硝唑和WR - 2721联合使用对放射敏感性的改变以及对致死毒性的改变进行了研究。在各个方面均观察到了相互作用。在米索硝唑存在的情况下，WR - 2721的毒性增加。如果添加敏化剂，皮肤和肿瘤的WR - 2721辐射防护作用均降低。同样，当存在WR - 2721时，米索硝唑的放射增敏作用减弱。这些结果表明在辐射损伤部位存在相互作用，并且还证明WR - 2721能够充分渗透到缺氧肿瘤细胞中。
