Nagy L, Mózsik G, Tárnok F, Szalai M, Póth I, Jávor T
Pharmacology. 1978;16(3):135-41. doi: 10.1159/000136758.
The effects of prostaglandin E2 (PGE2) have been studied on the gastric secretion and the serum level of immunoreactive gastrin in pylorus-ligated and antrectomized rats. It has been observed that: (1) a significant inhibition of gastric secretion (volume and acid output) was caused by PGE2, applied in doses of 75, 150 and 300 microgram/kg body weight, subcutaneously, in both pylorus-occluded and antrectomized rats: PGE2 inhibition of gastric secretion was more pronounced in rats with antrectomy; (2) no significant changes were found in the serum gastrin levels of both pylorus-ligated and antrectomized rats, and (3) no significant changes in serum levels of immunoreactive gastrin were produced by different doses of PGE2, in comparison with their marked inhibitory effects on gastric H+ secretion. It was concluded that there is no essential role of the immunoreactive gastrin, originated from the antral part of the stomach, neither in development of gastric hypersecretion nor in PGE2-produced inhibition on gastric secretion of the pylorus-occluded rats.
研究了前列腺素E2（PGE2）对幽门结扎和胃窦切除大鼠胃分泌及血清免疫反应性胃泌素水平的影响。观察到：（1）在幽门结扎和胃窦切除的大鼠中，皮下注射剂量为75、150和300微克/千克体重的PGE2可显著抑制胃分泌（体积和酸分泌量）：PGE2对胃窦切除大鼠胃分泌的抑制作用更明显；（2）幽门结扎和胃窦切除大鼠的血清胃泌素水平均未发现显著变化；（3）与PGE2对胃H⁺分泌的显著抑制作用相比，不同剂量的PGE2对血清免疫反应性胃泌素水平未产生显著变化。得出结论：源自胃窦部的免疫反应性胃泌素在幽门结扎大鼠胃分泌过多的发生以及PGE2对胃分泌的抑制作用中均无重要作用。
