Ochs R H, Katz A S, Edmunds L H, Miller C L, Epstein D M
J Thorac Cardiovasc Surg. 1982 Sep;84(3):359-66.
Eighty-one patients with resectable primary peripheral lung carcinomas were studied to determine the effect of associated scarring on prognosis. Twelve tumors (15%) originated from bronchi. 24 (30%) were associated with scars, and 45 (55%) were not associated with either bronchus or scar (non-scar). Scar carcinomas differed significantly in cell type from bronchogenic and non-scar tumors in that 21 (88%) scar carcinomas were either adenocarcinomas or bronchioloalveolar carcinomas (p less than 0.001). Origin (bronchogenic, scar, non-scar) independent of cell type and tumor stage did not significantly influence survival. Stage of disease independent of cell type or origin affected survival (p less than 0.0001), as did cell type independent of tumor stage or origin (p less than 0.0001). Stage I disease and bronchioloalveolar carcinoma were associated with longer survival, while Stage II or III disease, small cell anaplastic carcinoma, and adenocarcinoma were associated with reduced survival. We conclude that associated scar influences cell type of peripheral lung carcinoma but does not influence patient survival, even among patients with similar cell type and stage of disease.
对81例可切除的原发性周围型肺癌患者进行了研究，以确定相关瘢痕对预后的影响。12例肿瘤（15%）起源于支气管。24例（30%）与瘢痕相关，45例（55%）既不与支气管也不与瘢痕相关（非瘢痕）。瘢痕癌在细胞类型上与支气管源性肿瘤和非瘢痕肿瘤有显著差异，21例（88%）瘢痕癌为腺癌或细支气管肺泡癌（p<0.001）。独立于细胞类型和肿瘤分期的起源（支气管源性、瘢痕性、非瘢痕性）对生存率没有显著影响。独立于细胞类型或起源的疾病分期影响生存率（p<0.0001），独立于肿瘤分期或起源的细胞类型也影响生存率（p<0.0001）。I期疾病和细支气管肺泡癌与较长的生存期相关，而II期或III期疾病、小细胞间变癌和腺癌与生存期缩短相关。我们得出结论，相关瘢痕影响周围型肺癌的细胞类型，但不影响患者生存率，即使在疾病细胞类型和分期相似的患者中也是如此。
