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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Hymson D L, Hynes M D

Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(2):159-65. doi: 10.1016/s0278-5846(82)80191-7.

The performance of mice, trained to remain on a roto-rod, was significantly impaired by both morphine and ethanol. The behavioral impairment was dose dependent. 2. Naloxone (10, 30 and 100 mg/kg) was found to antagonize only the morphine-induced impairment of roto-rod performance. 3. Animals made tolerant to morphine did not perform better than non-tolerant animals when challenged with ethanol, but did perform better when challenged with morphine. As such, no cross tolerance developed between ethanol and morphine in this model. 4. These results suggest that the ethanol-induced impairment of roto-rod performance is not mediated via opioid mechanisms.

经过训练能在旋转杆上保持平衡的小鼠，其行为表现会因吗啡和乙醇而显著受损。行为损伤呈剂量依赖性。2. 发现纳洛酮（10、30和100毫克/千克）仅能拮抗吗啡引起的旋转杆行为表现损伤。3. 对吗啡产生耐受性的动物在接受乙醇刺激时表现并不比未耐受的动物好，但在接受吗啡刺激时表现更好。因此，在该模型中乙醇和吗啡之间未产生交叉耐受性。4. 这些结果表明，乙醇引起的旋转杆行为表现损伤并非通过阿片类机制介导。

Hymson D L, Hynes M D

Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(2):159-65. doi: 10.1016/s0278-5846(82)80191-7.

The performance of mice, trained to remain on a roto-rod, was significantly impaired by both morphine and ethanol. The behavioral impairment was dose dependent. 2. Naloxone (10, 30 and 100 mg/kg) was found to antagonize only the morphine-induced impairment of roto-rod performance. 3. Animals made tolerant to morphine did not perform better than non-tolerant animals when challenged with ethanol, but did perform better when challenged with morphine. As such, no cross tolerance developed between ethanol and morphine in this model. 4. These results suggest that the ethanol-induced impairment of roto-rod performance is not mediated via opioid mechanisms.

经过训练能在旋转杆上保持平衡的小鼠，其行为表现会因吗啡和乙醇而显著受损。行为损伤呈剂量依赖性。2. 发现纳洛酮（10、30和100毫克/千克）仅能拮抗吗啡引起的旋转杆行为表现损伤。3. 对吗啡产生耐受性的动物在接受乙醇刺激时表现并不比未耐受的动物好，但在接受吗啡刺激时表现更好。因此，在该模型中乙醇和吗啡之间未产生交叉耐受性。4. 这些结果表明，乙醇引起的旋转杆行为表现损伤并非通过阿片类机制介导。