Takahashi J S, Zatz M
Science. 1982 Sep 17;217(4565):1104-11. doi: 10.1126/science.6287576.
Daily rhythms in many behavioral, physiological, and biochemical functions are generated by endogenous oscillators that function as internal 24-hour clocks. Under natural conditions, these oscillators are synchronized to the daily environmental cycle of light and darkness. Recent advances in locating circadian pacemakers in the brain and in establishing model systems promise to shed light on the cellular and biochemical mechanisms involved in the generation and regulation of circadian rhythms.
许多行为、生理和生化功能的日常节律是由作为内部24小时时钟的内源性振荡器产生的。在自然条件下，这些振荡器与光和暗的日常环境周期同步。在大脑中定位昼夜节律起搏器以及建立模型系统方面的最新进展有望揭示参与昼夜节律产生和调节的细胞和生化机制。
