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纳洛酮对苯环己哌啶体温调节作用的拮抗作用。

Naloxone antagonism of the thermoregulatory effects of phencyclidine.

作者信息

Glick S D, Guido R A

出版信息

Science. 1982 Sep 24;217(4566):1272-3. doi: 10.1126/science.6287581.

DOI:10.1126/science.6287581
PMID:6287581
Abstract

Phencyclidine elicits hyperthermia at low doses and hypothermia at high doses in rats. Naloxone antagonizes both effects. Phencyclidine's effects on thermo-regulation are probably mediated by an interaction with a mu opiate receptor.

摘要

在大鼠中，苯环利定在低剂量时会引起体温过高，而在高剂量时会引起体温过低。纳洛酮可拮抗这两种效应。苯环利定对体温调节的作用可能是通过与μ阿片受体相互作用介导的。

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Science. 1982 Sep 24;217(4566):1272-3. doi: 10.1126/science.6287581.
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引用本文的文献

1
Comparison of effects of phencyclidine and methamphetamine on body temperature in mice: a possible role for histamine neurons in thermoregulation.
Naunyn Schmiedebergs Arch Pharmacol. 1986 Mar;332(3):293-6. doi: 10.1007/BF00504870.
2
Evidence for multiple opiate receptor involvement in different phencyclidine-induced unconditioned behaviors in rats.多种阿片受体参与大鼠不同苯环利定诱导的非条件性行为的证据。
Psychopharmacology (Berl). 1986;88(1):44-53. doi: 10.1007/BF00310511.
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Involvement of opioid receptors in phencyclidine-induced enhancement of brain histamine turnover in mice.
Naunyn Schmiedebergs Arch Pharmacol. 1987 Mar;335(3):285-9. doi: 10.1007/BF00172798.