Paterson A C, Isaacson C
Virchows Arch A Pathol Anat Histol. 1982;395(3):273-8. doi: 10.1007/BF00429353.
Hepatocellular carcinoma has been extensively studied in Southern Africa, and particularly its relationship to hepatitis B virus infection. Most of this work involved rural Black populations. In this study the impact of urbanization on this relationship is investigated. The material is derived from the laboratory records at Baragwanath Hospital which serves the Black urban community of Soweto, Cases autopsied during the periods 1956-1960 and 1976-1980 have been examined with regard to age, sex, underlying cirrhosis and presence of HBsAg in the non-tumour liver. In addition, all biopsies from 1955 to 1980 have been analysed with respect to age and sex. There is evidence of a significant increase in overall average age and in the proportion of female cases, while the percentage of HBsAg positive cases has fallen. Possible causes for these findings are considered.
肝细胞癌在南部非洲已得到广泛研究，尤其是其与乙型肝炎病毒感染的关系。这项工作大多涉及农村黑人人口。在本研究中，调查了城市化对这种关系的影响。材料取自为索韦托黑人城市社区服务的巴拉格瓦纳特医院的实验室记录。对1956 - 1960年和1976 - 1980年期间尸检的病例进行了年龄、性别、潜在肝硬化以及非肿瘤肝脏中HBsAg存在情况的检查。此外，对1955年至1980年期间的所有活检样本进行了年龄和性别的分析。有证据表明总体平均年龄和女性病例比例显著增加，而HBsAg阳性病例的百分比有所下降。文中考虑了这些发现的可能原因。
