Zaman S N, Melia W M, Johnson R D, Portmann B C, Johnson P J, Williams R
Lancet. 1985 Jun 15;1(8442):1357-60. doi: 10.1016/s0140-6736(85)91785-4.
In a prospective study of 613 patients with cirrhosis of different aetiological types increasing age, male sex, and non-UK nationality were found to be significant independent risk factors for the progression of cirrhosis to hepatocellular carcinoma. Seropositivity for hepatitis B surface antigen and the duration and aetiology of cirrhosis were not related to the development of the disease. Age and sex were also found to be significant risk factors when UK patients alone were considered. Seropositivity for hepatitis B surface antigen may be associated with hepatocellular carcinoma only because hepatitis B virus infection is a common cause of cirrhosis.
在一项针对613例不同病因类型肝硬化患者的前瞻性研究中，发现年龄增长、男性以及非英国国籍是肝硬化进展为肝细胞癌的重要独立危险因素。乙肝表面抗原血清阳性以及肝硬化的病程和病因与该疾病的发生无关。仅考虑英国患者时，年龄和性别也是重要的危险因素。乙肝表面抗原血清阳性可能仅因为乙肝病毒感染是肝硬化的常见病因而与肝细胞癌相关。
