Winterbourn C C
Biomed Biochim Acta. 1983;42(11-12):S134-8.
The production and fate of superoxide and other free radicals, and the role of superoxide dismutase in the red cell is considered. Superoxide reacts slowly and at a comparable rate with oxyhaemoglobin and methaemoglobin, but superoxide dismutase markedly accelerates oxidation of oxyhaemoglobin by oxidizing drugs or xenobiotics such as quinones or paraquat. The mechanism involves inhibition by the enzyme (via its reaction with superoxide) of methaemoglobin reduction by the drug radicals. The possibility that such inhibition of organic radical reactions by superoxide dismutase is one of its protective functions is discussed.
本文探讨了超氧化物和其他自由基的产生与归宿，以及超氧化物歧化酶在红细胞中的作用。超氧化物与氧合血红蛋白和高铁血红蛋白反应缓慢，且反应速率相当，但超氧化物歧化酶通过氧化药物或外源性物质（如醌类或百草枯）显著加速氧合血红蛋白的氧化。其机制涉及该酶（通过与超氧化物反应）抑制药物自由基对高铁血红蛋白的还原作用。文中讨论了超氧化物歧化酶对有机自由基反应的这种抑制作用可能是其保护功能之一的可能性。
