孕期胎盘分泌催乳素、促肾上腺皮质激素和免疫反应性β-内啡肽。

Placental secretion of prolactin, ACTH and immunoreactive beta-endorphin during pregnancy.

作者信息

Demura R, Odagiri E, Yoshimura M, Jibiki K, Adachi T, Shirota M, Demura H, Shizume K, Oouchi H

出版信息

Acta Endocrinol (Copenh). 1982 May;100(1):114-9. doi: 10.1530/acta.0.1000114.

DOI:10.1530/acta.0.1000114

Abstract

The placental secretion of Prl, ACTH and immunoreactive (IR)-beta-endorphin were examined in early and later pregnancy with a perfusion method and by determining tissue concentrations of these hormones. Prl was secreted mainly from decidual tissue during 5-6 h long perfusions. Tissue concentrations of Prl were also significantly higher in decidual than in trophoblastic tissue. In contrast, the tissue concentrations of hCG, hPL, ACTH and IR-beta-endorphin were significantly higher in decidual than in trophoblastic tissues. In contrast, the tissue concentrations of hCG, hPL, ACTH and IR-beta-endorphin were significantly higher in trophoblastic than in decidual tissues. Production of hCG and hPL was predominantly demonstrated in trophoblastic tissues by the perfusion method but ACTH and IR-beta-endorphin were too low to be detected by perfusion.

摘要

采用灌注法并通过测定这些激素的组织浓度，对妊娠早期和晚期胎盘分泌的催乳素（Prl）、促肾上腺皮质激素（ACTH）和免疫反应性（IR）β-内啡肽进行了检测。在长达5 - 6小时的灌注过程中，Prl主要由蜕膜组织分泌。蜕膜组织中Prl的组织浓度也显著高于滋养层组织。相比之下，绒毛膜促性腺激素（hCG）、人胎盘催乳素（hPL）、ACTH和IR-β-内啡肽的组织浓度在滋养层组织中显著高于蜕膜组织。通过灌注法在滋养层组织中主要检测到了hCG和hPL的产生，但ACTH和IR-β-内啡肽含量过低，无法通过灌注检测到。