Johnson F L, Balis F M
Am J Pediatr Hematol Oncol. 1982 Summer;4(2):217-21.
Two children being treated with combination chemotherapy and irradiation for localized, rightsided Wilms' tumor developed sudden enlargement of the liver with defects on liver scintigram resembling liver metastases. One child also developed pancytopenia. When chemotherapy was temporarily withheld in both children, hepatomegaly and scintigram abnormalities resolved. The planned courses of chemotherapy were subsequently completed without complications. The clinical course in our patients is compared to previously published experiences. Awareness of this complication could prevent the mistaken diagnosis of metastatic disease and emphasizes the care necessary when administering cytotoxic drugs to children receiving irradiation to all or a portion of the liver.
两名因局限性右侧肾母细胞瘤接受联合化疗和放疗的儿童，肝脏突然肿大，肝脏闪烁扫描显示有缺损，类似肝转移。其中一名儿童还出现了全血细胞减少。当两个孩子都暂时停用化疗时，肝肿大和闪烁扫描异常消失。随后按计划完成了化疗疗程，未出现并发症。将我们患者的临床病程与先前发表的经验进行了比较。认识到这种并发症可以防止对转移性疾病的错误诊断，并强调在给接受肝脏全部或部分照射的儿童使用细胞毒性药物时需要谨慎。
