McVeagh P, Ekert H
J Pediatr. 1975 Oct;87(4):627-8. doi: 10.1016/s0022-3476(75)80841-9.
Two children developed hepatotoxicity during treatment for right-sided Wilms Tumor. Treatment consisted of nephrectomy, irradiation, and chemotherapy with actinomycin D and vincristine. Hepatic enlargement, thrombocytopenia, and abnormalities in liver function and seen on the liver scan occurred at the time of the course of chemotherapy administered 20 days after completion of irradiation. These abnormalities disappeared when treatment was temporarily suspended. Vincristine and actinomycin D were subsequently reintroduced without evidence of hepatotoxicity. Actinomycin D after irradiation for right-sided Wilms tumor may produce severe liver toxicity.
两名儿童在右侧肾母细胞瘤治疗期间出现肝毒性。治疗包括肾切除术、放疗以及使用放线菌素D和长春新碱进行化疗。在放疗结束20天后进行化疗疗程时，出现肝脏肿大、血小板减少以及肝功能异常和肝脏扫描异常。当治疗暂时中断时，这些异常消失。随后重新使用长春新碱和放线菌素D，未出现肝毒性迹象。右侧肾母细胞瘤放疗后使用放线菌素D可能会产生严重的肝毒性。
