人γ-促黑素原通过刺激mRNA合成增强促肾上腺皮质激素诱导的肾上腺类固醇生成。
Human gamma-melanotropin precursor potentiates corticotropin-induced adrenal steroidogenesis by stimulating mRNA synthesis.
作者信息
Al-Dujaili E A, Williams B C, Edwards C R, Salacinski P, Lowry P J
出版信息
Biochem J. 1982 Apr 15;204(1):301-5. doi: 10.1042/bj2040301.
Abstract
Circulating human gamma-melanotropin precursor (76 amino acids) [N-POC(1-76) enhances the corticosterone and aldosterone response to corticotropin by isolated perfused rat adrenal cells [Al-Dujaili, Hope, Estivariz, Lowry & Edwards (1981) Nature (London) 291, 156-159]. Actinomycin D (4 x 10(-6) mol/litre) did not significantly affect corticotropin-induced corticosterone or aldosterone outputs, but completely inhibited the potentiating action of gamma-melanotropin precursor on rat adrenal cells. This suggests that the precursor enhances corticotropin-induced steroidogenesis via an increase in available mRNA produced from DNA transcription.
摘要
循环中的人γ-促黑素前体（76个氨基酸）[N-POC(1-76)]可增强离体灌注的大鼠肾上腺细胞对促肾上腺皮质激素的皮质酮和醛固酮反应[Al-Dujaili、Hope、Estivariz、Lowry和Edwards（1981年），《自然》（伦敦）291, 156 - 159]。放线菌素D（4×10⁻⁶摩尔/升）对促肾上腺皮质激素诱导的皮质酮或醛固酮产量没有显著影响，但完全抑制了γ-促黑素前体对大鼠肾上腺细胞的增强作用。这表明该前体通过增加由DNA转录产生的可用mRNA来增强促肾上腺皮质激素诱导的类固醇生成。
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