Turner G A, Ellis R D, Guthrie D, Latner A L, Ross W M, Skillen A W
Br J Obstet Gynaecol. 1982 Sep;89(9):760-4. doi: 10.1111/j.1471-0528.1982.tb05105.x.
Guanosine 3':5'-phosphate (cycle GMP) in urine has been used to monitor the response of patients with ovarian cancer to treatment. Changes in the cyclic GMP level appear to correlate well with clinical status in that the disappearance of clinically detectable tumour is associated with a drop in the level whereas a tumour recurrence is associated with an elevation. Serially measured cyclic GMP is valuable for detecting a recurrence of tumour growth in patients in clinical remission and can predate any clinical signs by as much as 10 months. In patients who show no response to treatment, cyclic GMP levels in urine are elevated in the majority of specimens collected.
尿中的鸟苷3':5'-磷酸（环鸟苷酸）已被用于监测卵巢癌患者的治疗反应。环鸟苷酸水平的变化似乎与临床状况密切相关，临床上可检测到的肿瘤消失与该水平下降相关，而肿瘤复发则与该水平升高相关。连续测量环鸟苷酸对于检测临床缓解期患者肿瘤生长的复发很有价值，并且可以比任何临床体征提前多达10个月出现。在对治疗无反应的患者中，大多数采集的标本中尿中环鸟苷酸水平升高。
