Refsum H E, Strømme S B
Scand J Clin Lab Invest. 1978 Feb;38(1):19-22. doi: 10.3109/00365517809108397.
Serum and urine osmolality and creatinine were measured in fifty-eight well-trained men, aged 21-57 years, in connection with three 70 km cross-country ski races taking place under essentially the same external circumstances, leading to slight dehydration. Although the race urine flow was low, 0.51 (0.05-1.10) ml/min, the urine osmolality and the urine to serum osmolality ratio were relatively low, averaging 860 (399-1220) mosm/kg H2O and 2.84 (1.32-4.10), respectively. Decreasing urine flow and endogenou- creatinine clearance were associated with decreasing urine to serum osmolality ratio, indicating declining urine concentrating ability. Thus, the data confirm the author's recent suggestion, based on the measurement of a limited number of urine solutes, that during prolonged heavy exercise a decrease in urine flow and glomerular filtration rate is accompanied by a decline in the urine concentrating ability.
对58名年龄在21至57岁之间、训练有素的男性，在三场基本相同外部环境下进行的70公里越野滑雪比赛期间测量了血清和尿液渗透压及肌酐，这些比赛导致了轻微脱水。尽管比赛期间尿流率较低，为0.51（0.05 - 1.10）毫升/分钟，但尿渗透压及尿与血清渗透压比值相对较低，分别平均为860（399 - 1220）毫摩尔/千克H₂O和2.84（1.32 - 4.10）。尿流率和内生肌酐清除率的降低与尿与血清渗透压比值的降低相关，表明尿浓缩能力下降。因此，这些数据证实了作者最近基于对有限数量尿溶质的测量所提出的观点，即在长时间剧烈运动期间，尿流率和肾小球滤过率的降低伴随着尿浓缩能力的下降。
