Yamamoto C, Matsui H
Brain Res. 1982 Jul 29;244(2):382-6. doi: 10.1016/0006-8993(82)90103-2.
Electrical activities of thin hippocampal sections of the guinea pig were studied in vitro during and after administration of black widow spider venom (BSV). In CA3 neurons, BSV induced spontaneous discharges which were suppressed by Co2+ or Mn2+. During BSV administration, trains of potential changes resembling excitatory postsynaptic potentials (EPSPs) were recorded intracellularly. The EPSP-like potentials were blocked by TTX. BSV seems to induce impulses in presynaptic fibers or terminals and thereby facilitates release of neurotransmitters.
在给予黑寡妇蜘蛛毒液（BSV）期间及之后，对豚鼠海马薄片的电活动进行了体外研究。在CA3神经元中，BSV诱导自发放电，这种放电可被Co2+或Mn2+抑制。在给予BSV期间，细胞内记录到一系列类似于兴奋性突触后电位（EPSP）的电位变化。类EPSP电位被TTX阻断。BSV似乎在突触前纤维或终末诱导冲动，从而促进神经递质的释放。
