Wilkinson M, Khan I
Brain Res Bull. 1982 May;8(5):547-9. doi: 10.1016/0361-9230(82)90014-4.
We have examined brain tissue from dystrophic mice (male 129/ReJ-dy and female 129 B6F1/J-dy) to determine whether CNS lesions may accompany the known muscular defects. In all brain regions examined we found a significant reduction in the numbers of beta-adrenergic binding sites when compared to brain from control mice. In contrast, the number of benzodiazepine binding sites appeared normal. These changes in adrenergic sites may be related to the known abnormally high excretion of catecholamines. Our results also emphasise the need to study extra-muscular sites in this disease.
我们检查了营养不良小鼠（雄性129/ReJ-dy和雌性129 B6F1/J-dy）的脑组织，以确定中枢神经系统病变是否可能伴随已知的肌肉缺陷。与对照小鼠的脑相比，在所有检查的脑区中，我们发现β-肾上腺素能结合位点的数量显著减少。相比之下，苯二氮䓬结合位点的数量似乎正常。肾上腺素能位点的这些变化可能与已知的儿茶酚胺异常高排泄有关。我们的结果还强调了在这种疾病中研究肌肉外部位的必要性。
