在灰盖鬼伞衰老过程中，线粒体结构基因是否会被选择性扩增？

Are mitochondrial structural genes selectively amplified during senescence in Podospora anserina?

作者信息

Wright R M, Horrum M A, Cummings D J

出版信息

Cell. 1982 Jun;29(2):505-15. doi: 10.1016/0092-8674(82)90167-2.

Abstract

Genetic and transcriptional maps have been constructed for the mitochondrial genome of the Ascomycete Podospora anserina. These data have been plotted on the restriction maps for Sal I, Xho I, Bam HI, Eco RI, BgI II and Hae III. We have characterized and cloned a new and unique senescent mitochondrial DNA (beta-event senDNA) and have organized all of the recognized senDNAs on the genomic maps. We make the observation that all of the known and characterized senDNAs are derived from specific genes or gene regions of the young mitochondrial genome. We have unambiguously assigned the alpha-event senDNA (the 2.6 kb monomer) to the oxi3 gene locus and the beta-event senDNA to the oxi2 gene locus.

摘要

已经构建了子囊菌Podospora anserina线粒体基因组的遗传图谱和转录图谱。这些数据已绘制在Sal I、Xho I、Bam HI、Eco RI、BgI II和Hae III的限制酶切图谱上。我们鉴定并克隆了一种新的独特的衰老线粒体DNA（β事件senDNA），并将所有已识别的senDNA排列在基因组图谱上。我们观察到，所有已知且已鉴定的senDNA均源自年轻线粒体基因组的特定基因或基因区域。我们已明确将α事件senDNA（2.6 kb单体）定位到oxi3基因座，将β事件senDNA定位到oxi2基因座。