非组蛋白HMG1和HMG2会改变DNA的螺旋结构。
Nonhistone proteins HMG1 and HMG2 change the DNA helical structure.
作者信息
Javaherian K, Liu J F, Wang J C
出版信息
Science. 1978 Mar 24;199(4335):1345-6. doi: 10.1126/science.628842.
PMID:628842
Abstract
Two chromatin nonhistone proteins (from calf thymus) of the high mobility group, HMG1 and HMG2, reduce the linking number (topological winding number) of a circular DNA if the covalent closure of the DNA is carried out in their presence. This indicates that these proteins can either unwind the double helix, or induce a supercoiling of the DNA.
摘要
两种来自小牛胸腺的高迁移率族染色质非组蛋白HMG1和HMG2，如果在其存在的情况下进行DNA的共价封闭，则会降低环状DNA的连环数（拓扑缠绕数）。这表明这些蛋白质要么能解开双螺旋，要么能诱导DNA超螺旋。
Zotero 插件