Sherry S H, Guay A T, Lee A K, Hedley Whyte E T, Federman M, Freidberg S R, Woolf P D
J Clin Endocrinol Metab. 1982 Nov;55(5):947-55. doi: 10.1210/jcem-55-5-947.
A pituitary tumor from a patient with severe Cushing's disease and marked hyperprolactinemia was extensively studied by immunohistochemical techniques. Tissues from two separate areas of the adenoma were found to contain similar cell proportions of PRL as well as ACTH and related peptides (beta-lipotropin, beta-endorphin, and alpha MSH). The tumor was composed of approximately 70% immunoreactive PRL cells and 5% ACTH-containing cells. Double immunostaining revealed that PRL or ACTH and related peptides were found in two distinct populations of tumor cells. These results document for the first time inappropriate synthesis and secretion of an unusual combination of pituitary hormones from a mixed pituitary adenoma.
采用免疫组化技术对一名患有严重库欣病和显著高催乳素血症患者的垂体肿瘤进行了广泛研究。发现腺瘤两个不同区域的组织中PRL以及促肾上腺皮质激素（ACTH）和相关肽（β-促脂素、β-内啡肽和α-促黑素）的细胞比例相似。该肿瘤约由70%的免疫反应性PRL细胞和5%的含ACTH细胞组成。双重免疫染色显示，PRL或ACTH及相关肽存在于两个不同的肿瘤细胞群中。这些结果首次证明了混合性垂体腺瘤异常合成和分泌了异常组合的垂体激素。
