库欣病患者垂体腺瘤中的促肾上腺皮质激素（ACTH）、β-促脂素（β-LPH）和β-内啡肽：β-LPH向β-内啡肽转化的激活
ACTH, beta-LPH and beta-endorphin in pituitary adenomas of the patients with Cushing's disease: activation of beta-LPH conversion to beta-endorphin.
作者信息
Suda T, Abe Y, Demura H, Demura R, Shizume K, Tamahashi N, Sasano N
出版信息
J Clin Endocrinol Metab. 1979 Sep;49(3):475-7. doi: 10.1210/jcem-49-3-475.
ACTH, beta-lipotropin (beta-LPH) and beta-endorphin concentrations were determined in pituitary adenomas of the patients with Cushing's disease. Immunoreactive ACTH and beta-endorphin were present in high concentrations and essentially equimolar amounts in pituitary adenomas. beta-LPH conversion to beta-endorphin was activated in pituitaries associated with ACTH/beta-LPH producing adenomas. Immunoreactive ACTH and beta-endorphin concentrations were markedly suppressed in the surrounding tissues.
测定了库欣病患者垂体腺瘤中促肾上腺皮质激素（ACTH）、β-促脂素（β-LPH）和β-内啡肽的浓度。免疫反应性ACTH和β-内啡肽在垂体腺瘤中浓度很高且基本等摩尔量存在。与产生ACTH/β-LPH的腺瘤相关的垂体中，β-LPH向β-内啡肽的转化被激活。周围组织中免疫反应性ACTH和β-内啡肽浓度明显受到抑制。
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