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库欣病患者垂体腺瘤中的促肾上腺皮质激素（ACTH）、β-促脂素（β-LPH）和β-内啡肽：β-LPH向β-内啡肽转化的激活

ACTH, beta-LPH and beta-endorphin in pituitary adenomas of the patients with Cushing's disease: activation of beta-LPH conversion to beta-endorphin.

作者信息

Suda T, Abe Y, Demura H, Demura R, Shizume K, Tamahashi N, Sasano N

出版信息

J Clin Endocrinol Metab. 1979 Sep;49(3):475-7. doi: 10.1210/jcem-49-3-475.

DOI:10.1210/jcem-49-3-475
PMID:224076
Abstract

ACTH, beta-lipotropin (beta-LPH) and beta-endorphin concentrations were determined in pituitary adenomas of the patients with Cushing's disease. Immunoreactive ACTH and beta-endorphin were present in high concentrations and essentially equimolar amounts in pituitary adenomas. beta-LPH conversion to beta-endorphin was activated in pituitaries associated with ACTH/beta-LPH producing adenomas. Immunoreactive ACTH and beta-endorphin concentrations were markedly suppressed in the surrounding tissues.

摘要

测定了库欣病患者垂体腺瘤中促肾上腺皮质激素（ACTH）、β-促脂素（β-LPH）和β-内啡肽的浓度。免疫反应性ACTH和β-内啡肽在垂体腺瘤中浓度很高且基本等摩尔量存在。与产生ACTH/β-LPH的腺瘤相关的垂体中，β-LPH向β-内啡肽的转化被激活。周围组织中免疫反应性ACTH和β-内啡肽浓度明显受到抑制。

相似文献

1
ACTH, beta-LPH and beta-endorphin in pituitary adenomas of the patients with Cushing's disease: activation of beta-LPH conversion to beta-endorphin.库欣病患者垂体腺瘤中的促肾上腺皮质激素（ACTH）、β-促脂素（β-LPH）和β-内啡肽：β-LPH向β-内啡肽转化的激活
J Clin Endocrinol Metab. 1979 Sep;49(3):475-7. doi: 10.1210/jcem-49-3-475.
2
[Lipocorticotropic peptides in Cushing's disease: in vitro studies].[库欣病中的促肾上腺皮质激素释放肽：体外研究]
Horm Res. 1980;13(4-5):242-58. doi: 10.1159/000179293.
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[Ectopic secretion of ACTH and of related peptides (LPHs, beta-endorphin, "16K"). Evidence for a common precursor].[促肾上腺皮质激素及相关肽（促脂解素、β-内啡肽、“16K”）的异位分泌。共同前体的证据]
Horm Res. 1980;13(4-5):291-301. doi: 10.1159/000179296.
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Concurrent production of adrenocorticotropin and prolactin from two distinct cell lines in a single pituitary adenoma: a detailed immunohistochemical analysis.单个垂体腺瘤中两种不同细胞系同时产生促肾上腺皮质激素和催乳素：详细的免疫组织化学分析
J Clin Endocrinol Metab. 1982 Nov;55(5):947-55. doi: 10.1210/jcem-55-5-947.
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Secretion of ACTH, LPH and beta-endophin from human pituitary tumours in vitro.人垂体肿瘤促肾上腺皮质激素、促脂解素及β-内啡肽的体外分泌
Clin Endocrinol (Oxf). 1980 Aug;13(2):197-205. doi: 10.1111/j.1365-2265.1980.tb01042.x.
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In vitro secretion of ACTH, beta-endorphin and beta-lipotropin in Cushing's disease and Nelson's syndrome.库欣病和尼尔森综合征中促肾上腺皮质激素、β-内啡肽和β-促脂素的体外分泌
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In vitro secretion of pro-opiomelanocortin (POMC) derived peptides in human ACTH-producing pituitary adenomas: evaluation of hormone ratios in different functional states.人促肾上腺皮质激素分泌型垂体腺瘤中阿片-促黑素细胞皮质素原（POMC）衍生肽的体外分泌：不同功能状态下激素比率的评估
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Endocrinology. 1986 Aug;119(2):720-30. doi: 10.1210/endo-119-2-720.
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[ACTH, beta-endorphin and lipotropins: physiopathological studies in man (author's transl)].促肾上腺皮质激素、β-内啡肽与促脂解素：人体生理病理学研究（作者译）
Ann Med Interne (Paris). 1982;133(3):148-51.

引用本文的文献

1
Multiple cellular forms of corticotrophs in surgically removed pituitary adenomas and periadenomatous tissue in Cushing's disease.库欣病手术切除的垂体腺瘤及腺瘤周围组织中促肾上腺皮质激素细胞的多种细胞形态
Am J Pathol. 1982 Mar;106(3):332-41.
2
Long-term culture of human corticotropin-secreting adenomas on extracellular matrix and evaluation of serum-free conditions. Secretory aspects.人促肾上腺皮质激素分泌腺瘤在细胞外基质上的长期培养及无血清条件评估。分泌方面。
Acta Neuropathol. 1986;71(1-2):111-8. doi: 10.1007/BF00687971.
3
Altered proopiomelanocortin gene expression in adrenocorticotropin-producing nonpituitary tumors. Comparative studies with corticotropic adenomas and normal pituitaries.
促肾上腺皮质激素分泌性非垂体肿瘤中阿黑皮素原基因表达的改变。与促肾上腺皮质激素腺瘤和正常垂体的比较研究。
J Clin Invest. 1985 Nov;76(5):1892-8. doi: 10.1172/JCI112184.