Kapoor A K, Nash A A, Wildy P
J Gen Virol. 1982 Jul;61 (Pt l):127-31. doi: 10.1099/0022-1317-61-1-127.
B cell responses of Balb/c mice were suppressed using sheep anti-mouse IgM serum. At 4 weeks, both B cell-suppressed and normal littermates were infected in the ear pinna with herpes simplex virus type 1 (HSV-1). The B cell-suppressed mice failed to produce neutralizing herpes antibodies in their sera but had a normal cell-mediated immunity (CMI) response as measured by a delayed hypersensitivity skin test. Although the infection was eliminated from the ear in both B cell-suppressed and normal mice by day 10 after infection, there was an indication that B cell-suppressed mice had a more florid primary infection of the peripheral and central nervous system and also a higher incidence of a latent infection. These results support the hypothesis that antibody is important in restricting the spread of virus to the central nervous system, whereas CMI is important in clearing the primary infection in the ear pinna.
使用羊抗小鼠IgM血清抑制Balb/c小鼠的B细胞反应。4周时，B细胞受抑制的小鼠和正常同窝小鼠均在耳廓接种1型单纯疱疹病毒（HSV-1）。B细胞受抑制的小鼠血清中未能产生中和性疱疹抗体，但通过迟发型超敏皮肤试验检测，其细胞介导免疫（CMI）反应正常。尽管在感染后第10天，B细胞受抑制的小鼠和正常小鼠耳部的感染均已消除，但有迹象表明，B细胞受抑制的小鼠外周和中枢神经系统的原发性感染更为严重，潜伏感染的发生率也更高。这些结果支持以下假说：抗体在限制病毒向中枢神经系统扩散方面很重要，而CMI在清除耳廓原发性感染方面很重要。
