大鼠交感神经节中环磷酸腺苷积累的调节：血管活性肠肽的作用
Regulation of cyclic AMP accumulation in a rat sympathetic ganglion: effects of vasoactive intestinal polypeptide.
作者信息
Volle R L, Patterson B A
出版信息
J Neurochem. 1982 Oct;39(4):1195-7. doi: 10.1111/j.1471-4159.1982.tb11516.x.
Abstract
Cyclic AMP accumulation in rat superior cervical ganglia during synaptic activity occurs by a noncholinergic, nonadrenergic process. Both preganglionic nerve stimulation and 4-aminopyridine increase ganglion cyclic AMP levels in the presence of atropine or phentolamine. Of the polypeptides tested as putative transmitters, vasoactive intestinal polypeptide (10(-6) M) causes ganglion cyclic AMP accumulation comparable to that produced by preganglionic nerve stimulation.
摘要
在突触活动期间，大鼠颈上神经节中环状AMP的积累是通过一种非胆碱能、非肾上腺素能过程发生的。在存在阿托品或酚妥拉明的情况下，节前神经刺激和4-氨基吡啶均可提高神经节环状AMP水平。在作为假定递质进行测试的多肽中，血管活性肠肽（10^(-6) M）引起的神经节环状AMP积累与节前神经刺激所产生的相当。
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