血管活性肠肽促进豚鼠气管中3',5'-环磷酸腺苷的积累。
Vasoactive intestinal polypeptide promotes cyclic adenosine 3',5'-monophosphate accumulation in guinea-pig trachea.
作者信息
Frandsen E K, Krishna G A, Said S I
出版信息
Br J Pharmacol. 1978 Mar;62(3):367-9. doi: 10.1111/j.1476-5381.1978.tb08471.x.
Abstract
Cyclic adenosine 3',5'-monophosphage (cyclic AMP) levels in guinea-pig tracheal rings increased on incubation with the vasoactive intestinal peptide (VIP). The effect was potentiated by the addition of theophylline. The results suggest that the tracheo-bronchial relaxant action of VIP may be mediated by stimulation of tracheal adenylyl cyclase.
摘要
豚鼠气管环中3',5'-环磷酸腺苷（环磷腺苷）水平在与血管活性肠肽（VIP）一起孵育时会升高。茶碱的加入会增强这种作用。结果表明，VIP的气管支气管舒张作用可能是通过刺激气管腺苷酸环化酶来介导的。
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