节前神经刺激期间豚鼠颈上神经节中的环磷酸腺苷
cAMP in guinea-pig superior cervical ganglia during preganglionic nerve stimulation.
作者信息
Volle R L, Patterson B
出版信息
Experientia. 1983 Dec 15;39(12):1345-6. doi: 10.1007/BF01990094.
PMID:6317429
Abstract
Preganglionic nerve stimulation or elevated [K+]o increase cAMP levels in isolated guinea-pig superior cervical ganglia, a ganglion lacking adrenergic inhibitory synaptic potentials. The cAMP response to K+ and nerve stimulation is not prevented by atropine or phentolamine. The regulation of cAMP content does not involve cholinergic or adrenergic mechanism. Of polypeptides tested, only VIP (5 X 10(-6) M) increases cAMP content to the extent observed with preganglionic nerve stimulation.
摘要
节前神经刺激或升高的细胞外钾离子浓度可使分离的豚鼠颈上神经节中的环磷酸腺苷（cAMP）水平升高，该神经节缺乏肾上腺素能抑制性突触电位。阿托品或酚妥拉明不能阻止对钾离子和神经刺激的cAMP反应。cAMP含量的调节不涉及胆碱能或肾上腺素能机制。在所测试的多肽中，只有血管活性肠肽（5×10⁻⁶ M）能使cAMP含量升高到节前神经刺激所观察到的程度。
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