氟处理大鼠肾脏和肝脏中葡萄糖-6-磷酸酶活性升高的一种可能机制。
A possible mechanism for elevation of glucose-6-phosphatase activity in kidney and liver of fluoride-treated rats.
作者信息
Suketa Y, Yamada M, Hasegawa J, Asao Y
出版信息
Mol Pharmacol. 1982 Jul;22(1):116-20.
PMID:6289068
Abstract
Glucose-6-phosphatase (EC 3.1.3.9) activity in kidney and liver was found to be markedly elevated 3 hr after a single large dose of fluoride (NaF, 35 mg/kg, i.p.). The increases in renal and hepatic glucose-6-phosphatase activity were completely suppressed by adrenalectomy. Moreover, the increments were markedly suppressed by injection of dibenamine as an alpha-adrenergic blocker or by injection of propranolol as a beta-adrenergic blocker.
摘要
单次大剂量注射氟化物（氟化钠，35毫克/千克，腹腔注射）3小时后，发现肾脏和肝脏中的葡萄糖-6-磷酸酶（EC 3.1.3.9）活性显著升高。肾上腺切除完全抑制了肾脏和肝脏中葡萄糖-6-磷酸酶活性的增加。此外，注射作为α-肾上腺素能阻滞剂的酚苄明或作为β-肾上腺素能阻滞剂的普萘洛尔可显著抑制这种增加。
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