Rigalli A, Alloatti R, Menoyo I, Puche R C
Departamento de Ciencias Fisiológicas, Facultad de Ciencias Médicas, Rosario, Argentina.
Arzneimittelforschung. 1995 Mar;45(3):289-92.
The effect of acute and chronic administration of sodium fluoride (NaF) or sodium monofluorophosphate (MFP) on the glucose homeostasis of the rat are compared. The oral administration of a single dose of 40 mumol/100 g b.w. of either compound produced similar increases in plasma glucose (up to 1.8 g/l) and diffusible fluoride (up to 130 mumol/l). In long-term experiments (three months of duration), treatment with NaF (a 5 mmol/l solution as the water supply) produced, in the first month of experiment, abnormal glucose tolerance tests and increased plasma diffusible fluoride levels (range: 2-12 mumol/l). Treatment with MFP, on the other hand, did not affect glucose homeostasis; plasma diffusible fluoride was always below 2 mumol/l. The results of these experiments indicate that glucose homeostasis is affected when plasma diffusible fluoride exceeds 5 mumol/l. The basal and glucose-stimulated insulin secretion of isolated Langerhans rat islets (incubated with solutions containing 2, 5, 10 and 20 mumol/l NaF) was significantly inhibited by 5 to 20 mumol/l fluoride. No effect was observed under similar conditions with MFP at concentrations of 2, 5, 10, 20 and 50 mumol/l.
比较了急性和慢性给予氟化钠（NaF）或单氟磷酸钠（MFP）对大鼠葡萄糖稳态的影响。口服单剂量40 μmol/100 g体重的这两种化合物中的任何一种，均可使血浆葡萄糖（升高至1.8 g/l）和可扩散氟化物（升高至130 μmol/l）出现类似程度的升高。在长期实验（为期三个月）中，用NaF（5 mmol/l溶液作为饮水）处理，在实验的第一个月，出现葡萄糖耐量试验异常，血浆可扩散氟化物水平升高（范围：2 - 12 μmol/l）。另一方面，用MFP处理不影响葡萄糖稳态；血浆可扩散氟化物始终低于2 μmol/l。这些实验结果表明，当血浆可扩散氟化物超过5 μmol/l时，葡萄糖稳态会受到影响。分离的大鼠胰岛（与含2、5、10和20 μmol/l NaF的溶液一起孵育）的基础胰岛素分泌和葡萄糖刺激的胰岛素分泌受到5至20 μmol/l氟化物的显著抑制。在类似条件下，2、5、10、20和50 μmol/l浓度的MFP未观察到影响。
