Total and local X-radiation effects on 18F uptake of bones.

Flourine uptake in rat bones under local and total-body X-irradiation was studied. Data were obtained by measurements with a scintillation crystal counter and in the case of limbs by means of macro and microautoradiographies. The autoradiographic studies showed a higher concentration of the isotope in the metaphyseal area of the endochondral plate. Irradiation produced a depression of 18F uptake in both cases. An alteration in the mineralization mechanism due to irradiation is presumed.