促肾上腺皮质激素肽和纳洛酮作用后小鼠脑内的区域葡萄糖代谢
Regional glucose metabolism in mouse brain following ACTH peptides and naloxone.
作者信息
Dunn A J, Hurd R W
出版信息
Pharmacol Biochem Behav. 1982 Jul;17(1):37-41. doi: 10.1016/0091-3057(82)90259-3.
Following intracerebroventricular (ICV) injection of ACTH1-24 significant decreases in 2-deoxyglucose (2DG) uptake were observed in frontal cortex and pyriform cortex, and an increase in thalamus. No such changes were observed following ICV MSH/ACTH4-10. Regional changes in 2DG uptake in olfactory bulb, pyriform cortex, thalamus and cerebellum were significantly correlated with the excessive grooming induced by ACTH1-24. Grooming behavior not induced by ACTH1-24 was not correlated with 2DG changes in any of these regions. Naloxone treatment did not significantly alter the regional pattern of 2DG uptake. In naloxone-pretreated mice ACTH1-24 did not induce significant changes in regional 2DG uptake. Following a series of footshocks, 2DG uptake increased in the hypothalamus, tectum and hippocampus. This pattern of changes is different from that observed following ICV ACTH1-24 and cannot therefore be attributed to ACTH secretion during the stress.
在脑室内（ICV）注射促肾上腺皮质激素1 - 24后，额叶皮质和梨状皮质的2 - 脱氧葡萄糖（2DG）摄取显著降低，而丘脑的摄取增加。脑室内注射促黑素/促肾上腺皮质激素4 - 10后未观察到此类变化。嗅球、梨状皮质、丘脑和小脑的2DG摄取区域变化与促肾上腺皮质激素1 - 24诱导的过度梳理行为显著相关。促肾上腺皮质激素1 - 24未诱导的梳理行为与这些区域中任何一个的2DG变化均无关联。纳洛酮治疗并未显著改变2DG摄取的区域模式。在经纳洛酮预处理的小鼠中，促肾上腺皮质激素1 - 24未诱导区域2DG摄取的显著变化。在一系列足部电击后，下丘脑、顶盖和海马体的2DG摄取增加。这种变化模式与脑室内注射促肾上腺皮质激素1 - 24后观察到的不同，因此不能归因于应激期间的促肾上腺皮质激素分泌。
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