纳洛酮可抑制大鼠血浆中肾上腺素对促肾上腺皮质激素的反应，但不抑制对2-脱氧-D-葡萄糖的反应。
Naloxone inhibits the plasma epinephrine response to ACTH but not to 2-deoxy-D-glucose in rats.
作者信息
Okajima T, Ikuyama S, Kato K, Ibayashi H
出版信息
Life Sci. 1984 Nov 26;35(22):2177-81. doi: 10.1016/0024-3205(84)90457-0.
Intravenous injection of (1-24) ACTH and 2-deoxy-d-glucose (2DG) stimulated the plasma epinephrine and norepinephrine levels in pentobarbital-anesthetized male rats. Naloxone, a specific opiate antagonist, inhibited the plasma epinephrine response to ACTH but not to 2DG. Norepinephrine release induced by ACTH or 2DG was not affected by naloxone. These results suggest that the opioid peptidergic synapse might be involved in the ACTH- but not in the 2DG-induced epinephrine release.
静脉注射（1 - 24）促肾上腺皮质激素（ACTH）和2 - 脱氧 - D - 葡萄糖（2DG）可刺激戊巴比妥麻醉的雄性大鼠血浆肾上腺素和去甲肾上腺素水平升高。特异性阿片拮抗剂纳洛酮可抑制血浆肾上腺素对ACTH的反应，但不影响对2DG的反应。纳洛酮不影响ACTH或2DG诱导的去甲肾上腺素释放。这些结果表明，阿片肽能突触可能参与了ACTH诱导的肾上腺素释放，而不参与2DG诱导的肾上腺素释放。
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