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放射治疗在骨巨细胞瘤(破骨细胞瘤)治疗中的地位:32例病例结果(作者译)

[The place of radiation therapy in the treatment of giant cell tumors of bone (osteoclastomas): results from 32 cases (author's transl)].

作者信息

Glanzmann C, Horst W

出版信息

Strahlentherapie. 1978 Feb;154(2):81-4.

PMID:628937
Abstract

Radiotherapeutic results of giant-cell tumors of the bone in 32 own cases are presented. The frequency of local recurrency was 30%, the 10-year survival rate was somewhat about 70% and in nearly 12% of primary benign giant-cell tumors there appeared malignant transformations (inclusive two fibrosarcomas in irradiated tissue). In other radiotherapeutic series, the frequency of malignant transformation is between 14 and 19%, in series with primary surgical therapy the rate of secundary malignant transformation is between 3 and 10%. Despite of the limited comparability of the surgical and radiotherapeutic material, we recommend in accordance with most authors in operable lesions surgical treatment. In inoperable lesions or when the lesion is not radically operable, radiation therapy has a definite place in the treatment of giant-cell tumors of the bone with a curative rate of about 80%.

摘要

本文呈现了32例骨巨细胞瘤患者的放射治疗结果。局部复发率为30%,10年生存率约为70%,近12%的原发性良性骨巨细胞瘤发生了恶性转变(包括放疗组织中的2例纤维肉瘤)。在其他放射治疗系列中,恶性转变的频率在14%至19%之间,在原发性手术治疗系列中,继发性恶性转变的发生率在3%至10%之间。尽管手术和放射治疗材料的可比性有限,但我们与大多数作者一致建议,对于可手术切除的病变应采用手术治疗。对于不可手术切除的病变或病变无法彻底手术切除时,放射治疗在骨巨细胞瘤的治疗中具有明确的地位,治愈率约为80%。

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