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电离辐射对人体中枢神经系统(CNS)纤毛细胞的影响——一项扫描电子显微镜研究

The effects of ionizing irradiation on the ciliated cells of the central nervous system (CNS) in man--a scanning electron microscopy study.

作者信息

Håkansson C H, von Mecklenburg C

出版信息

Scan Electron Microsc. 1981;4:93-8.

PMID:6289423
Abstract

In order to investigate the effects of radiotherapy on the ciliated ependymal lining of the CNS, samples were taken at autopsy from the lateral ventricles down to the IVth ventricles in patients irradiated for Glioblastoma multiforme in one hemisphere. Doses higher than 20 Gy affected the cilia and the lesions were more pronounced the heavier the dose. No regeneration of cilia were found in those regions which had received more than 20 Gy. In the areas irradiated with 20 - 15 Gy the cilia had a more normal form and cilia irradiated with less than 15 Gy were considered to be normal.

摘要

为了研究放疗对中枢神经系统纤毛室管膜内衬的影响,对一侧半球接受多形性胶质母细胞瘤放疗的患者进行尸检,从侧脑室直至第四脑室采集样本。高于20 Gy的剂量会影响纤毛,且剂量越大,损伤越明显。在接受超过20 Gy照射的区域未发现纤毛再生。在接受20 - 15 Gy照射的区域,纤毛形态较为正常,而接受低于15 Gy照射的纤毛被认为是正常的。

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