Heinonen E
Med Biol. 1976 Dec;54(5):341-6.
Precipitating adrenal antibodies are specifically associated with the moniliasis-polyendocrinopathy syndrome. This may include several simultaneous autoimmune disorders such as Addison's disease, hypoparathyroidism, thyroiditis, pernicious anaemia and ovarian failure often combined with moniliasis and alopecia. The antibodies react with two adrenal specific antigens present in man and in different animals. One of these antigens designated S-(soluble) antigen is present in all subcellular fractions and the other designated P-(particulate) antigen was found in precipitable form only in the mitochondrial fractions. Rabbits immunized with bovine adrenal homogenate and different subcellular fractions, produced three to four adrenal specific antibodies, which were qualitatively identical. The corresponding antigens were designed as S1-S4, one of which (S4) was strictly specific for bovine tissue. S1-, S2- and S3-antigens were identical in bovine and ovine adrenals, whereas a partial reaction of identity was found between ruminants and the S1- and S2-antigens of all other species tested. The S1- and S2-antigens seem to contain a variety of determinants, some common to all the species studied and some limited to certain species only. Of the four S-antigens only one (S1) in rabbits, was found to contain autoantigenic determinants. Comparative studies with sera from patients with the moniliasis-polyendocrinopathy syndrome indicate, that this molecule is the one with which human and rabbit antisera react.
沉淀性肾上腺抗体与念珠菌病 - 多内分泌病综合征有特异性关联。这可能包括几种同时存在的自身免疫性疾病，如艾迪生病、甲状旁腺功能减退症、甲状腺炎、恶性贫血和卵巢功能衰竭，常伴有念珠菌病和脱发。这些抗体与人和不同动物体内存在的两种肾上腺特异性抗原发生反应。其中一种抗原称为S - （可溶性）抗原，存在于所有亚细胞组分中，另一种称为P - （颗粒性）抗原，仅在线粒体组分中以可沉淀形式被发现。用牛肾上腺匀浆和不同亚细胞组分免疫的兔子产生了三到四种肾上腺特异性抗体，它们在性质上是相同的。相应的抗原被命名为S1 - S4，其中一种（S4）对牛组织具有严格的特异性。S1、S2和S3抗原在牛和羊的肾上腺中是相同的，而在反刍动物与所有其他测试物种的S1和S2抗原之间发现了部分相同反应。S1和S2抗原似乎包含多种决定簇，一些是所有研究物种共有的，一些仅局限于某些物种。在兔子体内发现的四种S抗原中，只有一种（S1）含有自身抗原决定簇。对念珠菌病 - 多内分泌病综合征患者血清的比较研究表明，这种分子就是人与兔抗血清发生反应的分子。
