Heinonen E, Krohn K, Perheentupa J, Aro A, Pelkonen R
Ann Clin Res. 1976 Aug;8(4):262-5.
The association of precipitating anti-adrenal antibodies with different subgroups of idiopathic Addison's disease were studied. We had previously found these antibodies in patients with the moniliasis-polyendocrinopathy syndrome. Sera of 36 adult patients suffering from different froms of Addison's disease were examined for the presence of adrenal antibodies demonstrable either by immunofluorescence (IFL) or by gel diffusion. 3 of the 17 patients with tuberculous and 17 of 19 patients with idiopathic Addison's disease had IFL antibodies but only one had precipitating antibodies. There was one typical case of Schmidt's syndrome, and four additional cases with Addison's disease combined with diabetes or thyroiditis, who may later develop the syndrome. None of htese patients had precipitating anti-adrenal antibodies. The only patients with precipitating adrenal antibodies had the moniliasis-polyendocrinopathy syndrome. He was not typical as Addison' disease appeared unusually late and he did not have hypoparathyroidism. The presence of precipitating anti-adrenal antibodies in this patient, and the absence of these in other groups of Addison's disease, is further evidence for the association of precipitating antibodies with the moniliasis-polyendocrinopathy syndrome.
我们研究了沉淀性抗肾上腺抗体与特发性艾迪生病不同亚组之间的关联。我们之前在念珠菌病-多内分泌腺病综合征患者中发现了这些抗体。对36例患有不同类型艾迪生病的成年患者的血清进行检测，以确定是否存在可通过免疫荧光（IFL）或凝胶扩散检测到的肾上腺抗体。17例结核性艾迪生病患者中有3例以及19例特发性艾迪生病患者中有17例有IFL抗体，但只有1例有沉淀性抗体。有1例典型的施密特综合征病例，另外还有4例艾迪生病合并糖尿病或甲状腺炎的病例，这些病例后期可能会发展为该综合征。这些患者均无沉淀性抗肾上腺抗体。唯一有沉淀性肾上腺抗体的患者患有念珠菌病-多内分泌腺病综合征。他并不典型，因为艾迪生病出现得异常晚，且他没有甲状旁腺功能减退症。该患者存在沉淀性抗肾上腺抗体，而其他艾迪生病组中不存在，这进一步证明了沉淀性抗体与念珠菌病-多内分泌腺病综合征之间的关联。
